Hormones and Cell Regulation, Volume 4

Regulation of cell volume in the perfused rat liver by hormones.

The effect of hormones on cell volume was studied in isolated perfused rat liver by assessing the intracellular water space as the difference between a [3H]inulin- and a [14C]urea-accessible space. The intracellular water space (control value 559 +/- 7 microliters/g of liver; n = 88) increased on addition of insulin (35 nM) or phenylephrine (5 microM) by 12 or 8% respectively, whereas it decrea...

Basic and Clinical Neuroscience, Volume 4, Number 4, Full Text

Volume regulatory hormones and plasma volume in pregnant women with sickle cell disorder

BACKGROUND Sickle cell disease (haemoglobin SS (HbSS)) mainly affects those of West African origin and is associated with hypervolaemia. Plasma volume rises by up to 50% in normal pregnancy but was previously found to be paradoxically contracted in late sickle cell pregnancy. The renin-angiotensin-aldosterone system is activated very early in human pregnancy to support the plasma volume expansi...

Regulation of -Cell Mass by Hormones and Growth Factors

Substantial new information has accumulated on molecular mechanisms of pancreas development, regulation of -cell gene expression, and the role of growth factors in the differentiation, growth, and regeneration of -cells. The present review focuses on some recent studies on the mechanism of action of cytokines such as growth hormone (GH) and prolactin (PRL) in -cell proliferation and gene expres...

Gastrointestinal hormones and the regulation of β-cell mass.

Type 2 diabetes occurs due to a relative deficit in β-cell mass or function. Glucagon-like peptide 1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), cholecystokinin (CCK), and gastrin are gastrointestinal hormones that are secreted in response to nutrient intake, regulating digestion, insulin secretion, satiety, and β-cell mass. In this review, we focus upon β-cell mass regulation....